Oprah Winfrey
Media executive and talk show host
Oprah Winfrey is an American media executive and television host who presented The Oprah Winfrey Show from 1986 to 2011 and founded the OWN cable network and Oprah's Book Club. She has talked publicly about her weight for decades, and in 2023 said she uses a GLP-1 medication. She co-wrote Enough, a book on obesity, with Yale researcher Ania Jastreboff.
Updated November 1, 2026 · 1 experiment
What Oprah Winfrey has tried
1 experiment we can source: 1 kept. Trying something is not recommending it; each entry says which.
Kept
GLP-1 drugsDrugs
Started 2023 · Does not recommend it to others
Started a GLP-1 drug in 2023, quit in January 2024 to test whether she could keep the weight off without it, then went back on it and now calls it a lifelong treatment; she frames it as a personal choice.
“It's going to be a lifetime thing.”
PEOPLE cover story via Yahoo, Oprah reveals she stopped using GLP-1s for 12 months (December 2025) · Status checked December 30, 2025 · Suggest a correction