NAD+ IV therapy

There are no outcome trials. A 2026 systematic review of 33 human studies of NAD+ boosting found no trial that tested IV NAD+ for aging or wellness [1]. The direct data are small. In a pilot study, NAD+ infused over six hours did not raise blood NAD+ for the first two hours, because the body cleared it quickly [2].

In a review of clinic records, people given 500 mg of NAD+ by IV on four straight days often had moderate to severe stomach symptoms, a faster heart rate and chest pressure during the drip, which took about 97 minutes on average [3]. Blood markers of liver, kidney and thyroid function did not change.

Taken by mouth, the NAD+ precursors NR and NMN raise NAD+ markers in blood [4], so a drip is not the only way to raise levels. Whether raising NAD+ slows aging is unproven, and NR did not extend lifespan in mice [5]. NAD+ is not an FDA-approved drug for any condition, and the FDA has warned about compounded IV NAD+ made from food-grade ingredients [6].

• NAD+ is not an FDA-approved drug. IV NAD+ is made by compounding pharmacies, and the FDA has reported chills, shaking and vomiting after infusions made from food-grade NAD+ [@fdanad].
• During infusions many people get chest pressure, nausea, stomach cramps or a faster heart rate, which is why clinics run them slowly [@reyna2026].
• Any IV carries a risk of vein irritation, bruising and infection at the needle site.
• Sessions often cost hundreds of dollars each, and no study shows a lasting benefit.
• People with heart, kidney or liver disease, or who are pregnant, should talk with a physician first.