What is a normal TSH level?
Updated October 31, 2026 · 22 sources · Written by the AumniVIDA team
UnitsShort answer
Most labs use a normal adult TSH range of about 0.4 to 4.0 or 4.5 mIU/L, but the upper limit rises with age: in NHANES III it was 3.56 mIU/L at age 20 to 29 and 7.49 at 80 and over . Pregnancy needs trimester-specific ranges . Women run slightly higher than men .
TSH upper reference limit by age
- US, age 20 to 293.56 mIU/L
NHANES III, 97.5th centile (Surks 2007)
- Australia, age 403.75 mIU/L
Western Australia laboratory data (Kahapola-Arachchige 2012)
- Scotland, age 31 to 403.98 mIU/L
Tayside TEARS study, 97.5th centile (Vadiveloo 2013)
- Australia, age 905 mIU/L
Western Australia laboratory data (Kahapola-Arachchige 2012)
- Scotland, over 905.94 mIU/L
Tayside TEARS study, 97.5th centile (Vadiveloo 2013)
- US, age 80 and over7.49 mIU/L
NHANES III, 97.5th centile (Surks 2007)
Show the data
| Item | Value (mIU/L) | Low | High | Note |
|---|---|---|---|---|
| US, age 20 to 29 | 3.56 | NHANES III, 97.5th centile (Surks 2007) | ||
| Australia, age 40 | 3.75 | Western Australia laboratory data (Kahapola-Arachchige 2012) | ||
| Scotland, age 31 to 40 | 3.98 | Tayside TEARS study, 97.5th centile (Vadiveloo 2013) | ||
| Australia, age 90 | 5 | Western Australia laboratory data (Kahapola-Arachchige 2012) | ||
| Scotland, over 90 | 5.94 | Tayside TEARS study, 97.5th centile (Vadiveloo 2013) | ||
| US, age 80 and over | 7.49 | NHANES III, 97.5th centile (Surks 2007) |
Key takeaways
What is the normal TSH range for adults?
About 0.4 to 4.0 or 4.5 mIU/L, depending on the lab and assay. Large pooled studies use 0.45 to 4.49 mIU/L, and the ETA treats 4.0 to 10.0 as mildly raised.
Each lab sets its own range from its assay and population, so your report's range is the one to use. The pooled cohort studies behind most risk data define normal as 0.45 to 4.49 mIU/L [5][9] or 0.50 to 4.49 mIU/L [4]. Spencer's third-generation assay found a normal range of 0.39 to 4.6 mU/L [10]. The ETA calls 4.0 to 10.0 mU/L mildly increased [11].
Assays matter near the top of the range. Four common TSH assays agreed well below 2 mU/L but differed by about 1 mU/L at 4.0 [12]. Comparing results from two different labs can therefore mislead.
In the NHANES III reference population, the geometric mean TSH was 1.40 mIU/L [13], and 85% of people without thyroid disease were below 2.5 mIU/L [7]. Units: mIU/L, µIU/mL and mU/L are all the same number.
What is the normal TSH range by age?
The upper limit rises with age. In US adults without thyroid disease it was 3.56 mIU/L at 20 to 29 and 7.49 at 80 and over. Scottish and Australian data show the same rise, though smaller.
Sources: NHANES III [1], TEARS [14], Western Australia [12], Korea [15].
In NHANES III, 10.6% of people aged 20 to 29 without thyroid disease had TSH above 2.5 mIU/L, rising to 40% at 80 and over, and 70% of older people with TSH above 4.5 were inside their age-specific range [1]. A Dutch analysis of 7.6 million results found upper limits rising from age 50 in women and 60 in men [16]. In Western Australia, age-specific limits reclassified only 0.1% to 1.9% of results in most age bands, but more in people aged 85 and over [12].
The Korean data are a reminder that iodine intake shapes the range: TSH ran higher at every age and did not climb with age [15]. Many labs still print one adult range, so an older person's result flagged high may be ordinary for their age [17].
| Study | Younger adults | Oldest adults |
|---|---|---|
| US, NHANES III (97.5th centile) | 3.56 at 20 to 29 | 7.49 at 80 and over |
| Scotland, TEARS (97.5th centile) | 3.98 at 31 to 40 | 5.94 over 90 |
| Western Australia (laboratory data) | 3.75 at 40 | 5.0 at 90 |
| Korea, KNHANES VI (iodine-rich) | 6.42 at 19 to 29 | 6.58 at 70 and over |
TSH upper reference limit by age
- US, age 20 to 293.56 mIU/L
NHANES III, 97.5th centile (Surks 2007)
- Australia, age 403.75 mIU/L
Western Australia laboratory data (Kahapola-Arachchige 2012)
- Scotland, age 31 to 403.98 mIU/L
Tayside TEARS study, 97.5th centile (Vadiveloo 2013)
- Australia, age 905 mIU/L
Western Australia laboratory data (Kahapola-Arachchige 2012)
- Scotland, over 905.94 mIU/L
Tayside TEARS study, 97.5th centile (Vadiveloo 2013)
- US, age 80 and over7.49 mIU/L
NHANES III, 97.5th centile (Surks 2007)
Show the data
| Item | Value (mIU/L) | Low | High | Note |
|---|---|---|---|---|
| US, age 20 to 29 | 3.56 | NHANES III, 97.5th centile (Surks 2007) | ||
| Australia, age 40 | 3.75 | Western Australia laboratory data (Kahapola-Arachchige 2012) | ||
| Scotland, age 31 to 40 | 3.98 | Tayside TEARS study, 97.5th centile (Vadiveloo 2013) | ||
| Australia, age 90 | 5 | Western Australia laboratory data (Kahapola-Arachchige 2012) | ||
| Scotland, over 90 | 5.94 | Tayside TEARS study, 97.5th centile (Vadiveloo 2013) | ||
| US, age 80 and over | 7.49 | NHANES III, 97.5th centile (Surks 2007) |
Is the normal TSH range different for women and men?
Slightly. Women have higher TSH than men on average, but the difference is 0.1 mIU/L or less, so labs use the same range. Women are more likely to have thyroid antibodies and thyroid disease.
In 465,593 TSH results, females had significantly higher TSH and free T4 than males, but the gap did not exceed 0.1 mIU/L or 0.1 ng/dL [3]. NHANES III found higher TSH and more thyroid antibodies in women [13], and age-related rises started earlier in women (from 50) than men (from 60) in Dutch data [16].
The bigger difference for women is pregnancy, covered below, and menopause: NICE notes that symptoms of thyroid dysfunction in menopausal women may be mistaken for menopause [18].
What is a normal TSH in pregnancy?
Pregnancy uses its own trimester-specific ranges, ideally from the local population and assay. If none exist, the 2017 ATA guideline allowed an upper limit of about 4.0 mIU/L, or the nonpregnant upper limit minus 0.5 in the first trimester.
The ATA's 2017 guideline recommends population- and trimester-specific TSH and free T4 ranges calculated in women without thyroid disease, with optimal iodine and negative TPO antibodies [2][6]. When those are unavailable, it allowed a fixed TSH upper limit of 4.0 mU/L or subtracting 0.5 mU/L from the nonpregnant upper limit in the first trimester [6].
Real ranges vary widely. Across 22 cohorts with 63,198 women, the TSH upper limit ranged from 2.24 to 6.02 mU/L in the first trimester and 2.67 to 6.15 in the second, and the lower free T4 limit in the first trimester ranged from 0.61 to 1.03 ng/dL (7.8 to 13.2 pmol/L)7.8 to 13.2 pmol/L (0.61 to 1.03 ng/dL) [6]. Shortcut approaches missed many women with a treatment indication compared with trimester-specific ranges [19].
The ATA updated its pregnancy guideline in 2026 using GRADE methods [20]. Thyroid testing and treatment in pregnancy or when trying to conceive should always run through a clinician.
What is the optimal TSH range?
There is no agreed optimal TSH for people who are not on treatment. Some experts favour an upper limit of 2.5 mIU/L; most guidelines keep the wider range. For people on levothyroxine, the ETA suggested aiming for 0.4 to 2.5 mU/L, a target set by a clinician.
Wartofsky and Dickey argued that more than 95% of normal people have TSH below 2.5 mU/L and that values above it often reflect early Hashimoto disease [21]. Surks and colleagues countered that lowering the limit would label 9.7% of the reference population, about 20.6 million Americans, as having thyroid disease without evidence that treatment helps [7].
Treatment trials since then have not found symptom benefits from lowering TSH in subclinical hypothyroidism [8][22]. For people already on levothyroxine, the ETA suggested that most adults aim for a stable TSH in the lower half of the range, 0.4 to 2.5 mU/L [11]; this is a clinician's target, not a reason to change a dose yourself.
More on this debate is on the TSH hub.

More about TSH
- TSH: the full guideTSH (thyroid-stimulating hormone) is the pituitary hormone that tells the thyroid how much T4 and T3 to make .
- What does a low TSH mean?A low TSH, below about 0.4 mIU/L, usually means the thyroid is making too much hormone or a person takes more thyroid hormone than needed .
- What does a high TSH mean?A high TSH, above about 4.0 to 4.5 mIU/L, usually means the thyroid is underactive and the pituitary is pushing harder .
- TSH test: fasting, timing and reflex testingA TSH test is a routine blood draw that usually needs no fasting, but TSH is higher in the morning and falls after a meal .
- TSH vs free T4: how they work togetherTSH is the pituitary's signal to the thyroid; free T4 is the unbound hormone the thyroid releases in response.
Common questions
What is a normal TSH level for a woman by age?
Is a TSH of 2.5 normal?
Yes. A TSH of 2.5 mIU/L is inside every standard adult range; 85% of people without thyroid disease are below it [7].
Is a TSH of 4.5 normal?
Does TSH go up in pregnancy?
Sources
- 1.Surks MI, Hollowell JG. Age-specific distribution of serum thyrotropin and antithyroid antibodies in the US population: implications for the prevalence of subclinical hypothyroidism. J Clin Endocrinol Metab, 2007. doi:10.1210/jc.2007-1499
- 2.Alexander EK, Pearce EN, Brent GA, et al. 2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum. Thyroid, 2017. doi:10.1089/thy.2016.0457
- 3.Ehrenkranz J, Bach PR, Snow GL, et al. Circadian and Circannual Rhythms in Thyroid Hormones: Determining the TSH and Free T4 Reference Intervals Based Upon Time of Day, Age, and Sex. Thyroid, 2015. doi:10.1089/thy.2014.0589
- 4.Rodondi N, den Elzen WP, Bauer DC, et al. Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA, 2010. doi:10.1001/jama.2010.1361
- 5.Collet TH, Gussekloo J, Bauer DC, et al. Subclinical hyperthyroidism and the risk of coronary heart disease and mortality. Arch Intern Med, 2012. doi:10.1001/archinternmed.2012.402
- 6.Osinga JAJ, Derakhshan A, Palomaki GE, et al. TSH and FT4 Reference Intervals in Pregnancy: A Systematic Review and Individual Participant Data Meta-Analysis. J Clin Endocrinol Metab, 2022. doi:10.1210/clinem/dgac425
- 7.Surks MI, Goswami G, Daniels GH. The thyrotropin reference range should remain unchanged. J Clin Endocrinol Metab, 2005. doi:10.1210/jc.2005-0170
- 8.Stott DJ, Rodondi N, Kearney PM, et al. Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism. N Engl J Med, 2017. doi:10.1056/NEJMoa1603825
- 9.Blum MR, Bauer DC, Collet TH, et al. Subclinical thyroid dysfunction and fracture risk: a meta-analysis. JAMA, 2015. doi:10.1001/jama.2015.5161
- 10.Spencer CA, LoPresti JS, Patel A, et al. Applications of a new chemiluminometric thyrotropin assay to subnormal measurement. J Clin Endocrinol Metab, 1990. doi:10.1210/jcem-70-2-453
- 11.Pearce SH, Brabant G, Duntas LH, et al. 2013 ETA Guideline: Management of Subclinical Hypothyroidism. Eur Thyroid J, 2013. doi:10.1159/000356507
- 12.Kahapola-Arachchige KM, Hadlow N, Wardrop R, et al. Age-specific TSH reference ranges have minimal impact on the diagnosis of thyroid dysfunction. Clin Endocrinol (Oxf), 2012. doi:10.1111/j.1365-2265.2012.04463.x
- 13.Hollowell JG, Staehling NW, Flanders WD, et al. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab, 2002. doi:10.1210/jcem.87.2.8182
- 14.Vadiveloo T, Donnan PT, Murphy MJ, et al. Age- and gender-specific TSH reference intervals in people with no obvious thyroid disease in Tayside, Scotland: the Thyroid Epidemiology, Audit, and Research Study (TEARS). J Clin Endocrinol Metab, 2013. doi:10.1210/jc.2012-3191
- 15.Kwon H, Kim WG, Jeon MJ, et al. Age-specific reference interval of serum TSH levels is high in adolescence in an iodine excess area: Korea national health and nutrition examination survey data. Endocrine, 2017. doi:10.1007/s12020-017-1375-5
- 16.Jansen HI, Dirks NF, Hillebrand JJ, et al. Age-Specific Reference Intervals for Thyroid-Stimulating Hormones and Free Thyroxine to Optimize Diagnosis of Thyroid Disease. Thyroid, 2024. doi:10.1089/thy.2024.0346
- 17.Biondi B, Cappola AR, Cooper DS. Subclinical Hypothyroidism: A Review. JAMA, 2019. doi:10.1001/jama.2019.9052
- 18.National Institute for Health and Care Excellence. Thyroid disease: assessment and management (NICE guideline NG145). NICE, 2019. Link
- 19.Osinga JAJ, Derakhshan A, Feldt-Rasmussen U, et al. TSH and FT4 Reference Interval Recommendations and Prevalence of Gestational Thyroid Dysfunction: Quantification of Current Diagnostic Approaches. J Clin Endocrinol Metab, 2024. doi:10.1210/clinem/dgad564
- 20.Korevaar TIM, Leung AM, Alexander EK, et al. American Thyroid Association 2026 Guidelines for Thyroid Disease in Preconception, Pregnancy, and Postpartum. Thyroid, 2026. doi:10.1177/10507256261445624
- 21.Wartofsky L, Dickey RA. The evidence for a narrower thyrotropin reference range is compelling. J Clin Endocrinol Metab, 2005. doi:10.1210/jc.2005-0455
- 22.Feller M, Snel M, Moutzouri E, et al. Association of Thyroid Hormone Therapy With Quality of Life and Thyroid-Related Symptoms in Patients With Subclinical Hypothyroidism: A Systematic Review and Meta-analysis. JAMA, 2018. doi:10.1001/jama.2018.13770