Large daily supplement stacks
What is large daily supplement stacks?
A supplement stack is a set of pills and powders taken every day, often dozens at once, such as vitamins, minerals, fish oil, NAD boosters and plant compounds. Longevity enthusiasts build large stacks hoping to slow aging. Large trials find little or no benefit for death, heart disease or cancer from most vitamins, and a few cause harm.
Listed here because well-known people have tried it on themselves. Trying something is not recommending it; each entry says whether the person tells others to do it.
Who has tried it
Tried by 3 people we can source: 3 kept.
Kept
Ray KurzweilFuturist and inventor
Dates not stated · Does not recommend it to others
Takes about 70 or 80 supplements a day, some by injection, alongside a cholesterol drug, as part of his plan to stay healthy until medicine can beat aging.
“Then I take maybe 70 or 80 supplements a day, some through injections.”
Boston Magazine, Futurist Ray Kurzweil says humanity is seven years away from beating disease (February 2026) · Status checked February 11, 2026 · Suggest a correction
Bryan JohnsonEntrepreneur, founder of BlueprintBlueprint (Bryan Johnson)
Dates not stated · Recommends it to others
Takes a daily stack of capsules, powders and oils listed in his protocol, and points readers to the Blueprint stack, which his company sells.
“I’ll take the following pills”
Bryan Johnson, Bryan's Protocol (checked November 2026) · Status checked November 1, 2026 · Suggest a correction
David SinclairGeneticist at Harvard Medical School, author of Lifespan
Dates not stated · Does not recommend it to others
Described taking about 1 g of NMN each morning with coffee and about 1 g of resveratrol stirred into yogurt, as his personal routine rather than advice.
“It is a gram of resveratrol, whatever I pour out into my yogurt.”
FoundMyFitness, Dr. David Sinclair's personal dosage and supplementation habits (November 2019) · Status checked November 7, 2019 · Suggest a correction
What the evidence shows
No trial has tested a large personal stack, so the evidence comes from trials of single supplements and multivitamins. A review for the US Preventive Services Task Force of 84 studies and about 740,000 people found little or no benefit for cardiovascular disease, cancer or death, apart from a small drop in cancer with multivitamins [1]. In the Physicians' Health Study II, a daily multivitamin cut total cancer by 8% over 11 years in male doctors [2], and in COSMOS a multivitamin modestly slowed memory decline in older adults [3].
In observational data from 390,124 healthy US adults, daily multivitamin users did not live longer than nonusers [4]. Some single supplements cause harm. Vitamin E raised prostate cancer risk by 17% in a large trial [5], and across 78 trials, antioxidants such as beta carotene, vitamin A and vitamin E slightly raised mortality in the trials at low risk of bias [6].
Unknown: what dozens of products taken together do, how they interact with each other and with drugs, and whether newer longevity compounds such as NAD precursors help people. Supplements are not approved by the FDA for safety or effect before they are sold, and doses and purity vary by brand.
Safety
- In the US, the FDA does not approve supplements before sale. Labels can be wrong, and some products contain undeclared drugs or contaminants.
- High doses of vitamin E, vitamin A and beta carotene have raised the risk of cancer or death in trials. Beta carotene is riskiest for smokers.
- Some supplements interact with drugs. St John's wort, fish oil, vitamin K and red yeast rice can change how blood thinners, statins and other medicines work.
- People who are pregnant, take prescription drugs, or have kidney or liver disease should check each product with a clinician or pharmacist.
- Fixing a measured deficiency, such as low vitamin B12 or vitamin D, is a different decision from taking dozens of products for longevity.
Common questions
How many supplements does Ray Kurzweil take?
About 70 or 80 a day, some by injection, he said in February 2026. Earlier profiles reported far higher counts.
What supplements does Bryan Johnson take?
His published protocol lists a daily stack of capsules and powders, such as his company's Essentials capsules, Longevity Mix and omega-3s. He recommends the stack to readers, and his company sells it.
What supplements does David Sinclair take?
In 2019 he described taking about 1 g of NMN and 1 g of resveratrol each morning. He presents this as his own routine, not a recommendation.
Do multivitamins help you live longer?
Sources
- 1.O'Connor EA, Evans CV, Ivlev I, et al. Vitamin and Mineral Supplements for the Primary Prevention of Cardiovascular Disease and Cancer: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force. JAMA, 2022. doi:10.1001/jama.2021.15650
- 2.Gaziano JM, Sesso HD, Christen WG, et al. Multivitamins in the prevention of cancer in men: the Physicians' Health Study II randomized controlled trial. JAMA, 2012. doi:10.1001/jama.2012.14641
- 3.Vyas CM, Manson JE, Sesso HD, et al. Effect of multivitamin-mineral supplementation versus placebo on cognitive function: results from the clinic subcohort of the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial and meta-analysis of 3 cognitive studies within COSMOS. Am J Clin Nutr, 2024. doi:10.1016/j.ajcnut.2023.12.011
- 4.Loftfield E, O'Connell CP, Abnet CC, et al. Multivitamin Use and Mortality Risk in 3 Prospective US Cohorts. JAMA Netw Open, 2024. doi:10.1001/jamanetworkopen.2024.18729
- 5.Klein EA, Thompson IM Jr, Tangen CM, et al. Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA, 2011. doi:10.1001/jama.2011.1437
- 6.Bjelakovic G, Nikolova D, Gluud LL, et al. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev, 2012. doi:10.1002/14651858.CD007176.pub2